Distinct genomic landscapes characterize mismatch repair deficiency(dMMR) microsatellite instability high


Jingyuan Wang, Joanne Xiu, Alex Farrell, Francesca Battaglin, Hiroyuki Arai, Joshua Millstein, Shivani Soni, Wu Zhang, Anthony Shields, Axel Grothey, Benjamin Weinberg, John Marshall, Emil Lou, Moh’d Khushman, Davendra Sohal, Michael Hall, Matthew Oberley, David Spetzler, Heinz-Josef Lenz


  • TMB-H was reported to be predictive of response to immune checkpoint inhibitors[1-2].
  • However, genomic signatures contributing to TMB-H independent from dMMR/MSI-H status are not well-studied.
  • We aimed to characterize specific molecular features of a large cohort of MSS GI tumors with TMB-H.


  • This is the largest study to investigate the distinct molecular landscape of dMMR/MSI-H GI cancers with different degrees of TMB. These data may inform our understanding of the efficacy of ICB in dMMR/MSI-H GI tumors.
Download Publication