Reveal a more complete
molecular blueprint for
precision oncology.

The most comprehensive tumor profile available.

Order a test​

Comprehensive molecular profiling results to improve patient outcomes.

The Caris molecular profiling approach assesses DNA, RNA and proteins to reveal the highest quality molecular blueprint to guide more precise and individualized treatment decisions. As the first and most experienced tumor profiling provider, we provide the critical molecular information when you need it most to improve patient outcomes.

The most comprehensive tumor profile available.

Order Caris Testing

A better blueprint for cancer treatment.

The precision medicine era has arrived and molecular profiling has become standard of care for many cancer types, recommended by the NCCN Guidelines® and required for certain therapies (companion diagnostics). More than ever, oncologists deserve a trusted profiling partner to provide reliable, high-quality molecular information to guide more precise and individualized treatment decisions.

Caris molecular profiling identifies key molecular features of cancer and provides clinical insights to aid oncologists in personalizing cancer therapies for their solid tumor cancer patients. Caris helps oncologists:

  • Navigate among therapies with potential benefit.
  • Identify therapies that may not have been considered.
  • Determine drugs with potential lack of benefit (avoiding unnecessary toxicities and costs).
  • Match patients to clinical trials.

Whole Exome Sequencing
(Mutations, Indels & Copy Number Alterations)


Whole Transcriptome Sequencing
(Fusions & Variant Transcripts)



Outsmarting Cancer with Artificial Intelligence

Caris has one of the largest and most comprehensive databases of combined molecular and clinical outcomes data in the world, and we are actively employing advanced AI and machine learning capabilities with the database to identify unique molecular signatures. These molecular signatures can be used to better identify cancer subtypes and predict patient response to certain therapies in ways never before possible.

Predict the Benefit from mCRC Standard-of-Care Chemotherapy with MI FOLFOXai

MI FOLFOXai, the first clinically validated, AI-powered molecular predictor of chemotherapy efficacy for metastatic colorectal cancer (mCRC) patients. Gauge a mCRC patient’s likelihood of benefit from first-line FOLFOX+BV followed by FOLFIRI+BV, versus FOLFIRI+BV followed by FOLFOX+BV treatment.

Identify Tumor Origin and Guide Treatment with MI GPSai

Better manage cancers of unknown primary (CUP) or cases with atypical clinical presentation or clinical ambiguity to improve outcomes. MI GPSai analyzes genomic and transcriptomic data to match a tumor’s molecular signature across 21 cancer types from the Caris database and can help physicians and pathologists confirm tumor of origin.

Caris Molecular Tumor Board

The Caris Molecular Tumor Board provides the opportunity to interact with cancer experts from across the country to review molecular information on specific patient cases of a requesting oncologist. This on-demand platform enables oncologists to focus their efforts on what matters most – developing the most informed and personalized treatment strategies for their patients.

  • Collaboration – Specialists from different institutions working together to ensure the appropriate diagnostic tests and treatment options are being considered for your patients.
  • Expert Review & Interpretation – Streamlined process allows each patient case submitted to be personally evaluated and discussed by members of the Caris Molecular Tumor Board.
  • Broad Review of Treatment Options – Reviews beyond the standard of care therapies, with recommendations that could include FDA-approved treatments, clinical trials of matched targeted therapies, and additional tumor or germline genetic testing options.
  • Virtual Platform – Allows oncologists to post and review patient medical records and other patient data from different parts of the country while allowing their patients to be treated within their own community.

Patient Stories and Education

What Causes Cancer? | Central Principles of Molecular Biology
DNA, RNA, & Proteins | Central Principles of Molecular Biology
Gene Expression | Central Principles of Molecular Biology
A Better Way to Fight Cancer | Caris Molecular Profiling
What’s in a Cell? | Central Principles of Molecular Biology
Christie’s Story: Metastatic Lung Cancer Survivor
Tissue-Based Comprehensive Molecular Profiling
Comprehensive Molecular Profiling and You
Caris Life Sciences Comprehensive Molecular Profiling Lab Tour
Colon Cancer: Caris Molecular Profiling Reveals New Therapies for Patient
Breast Cancer: Caris Molecular Profiling Reveals New Drug Options

Molecular Profiling Technology

Our comprehensive profiling approach to assess DNA, RNA, and proteins reveals the highest quality molecular blueprint.

Clinical Trials

We offer unique precision medicine services that are designed to maximize access to clinical trials that help empower physicians and strengthen patient treatment plans.

Research and Publications

We contribute to the body of research in oncology to advance the understanding of molecular science and further enable the delivery of precision medicine.​


If you have questions about Caris molecular profiling please contact us today.