Caris GPSai

Caris GPSai™, a Genomic Probability Score, uses whole exome (DNA) sequencing and whole transcriptome (RNA) sequencing coupled with machine learning to aid in identifying the tissue of origin.

Identify Tumor Origin and Improve Treatment Decisions with Caris GPSai

Cancer of Unknown Primary (CUP) diagnosis is typically treated empirically and has very poor outcomes, with median overall survival less than one year.1 Caris GPSai™, a Genomic Probability Score, uses whole exome (DNA) and whole transcriptome (RNA) sequencing coupled with trained and validated neural networks to aid in identifying the tissue of origin.
Caris GPSai analyzes genomic and transcriptomic data to match a tumor’s molecular signature to one or more of 90 cancer categories from the Caris database. GPSai provides additional insight to help oncologists better manage CUP or cases with atypical clinical presentation or clinical ambiguity.

Caris GPSai™ is included for all CUP cases and also may be selected on the requisition for other tumor types.

Enhance Diagnostic Confidence with Artificial Intelligence

Considering that rates of inaccurate diagnosis range between 3% and 9%2, Caris GPSai provides an integral part of quality control and may lead to improved diagnostic accuracy.

The Caris GPSai algorithm was trained and retrospectively validated on over 250,000 cases from the Caris database. The algorithm was then validated prospectively on an additional 3,200 MI Tumor Seek Hybrid™ cases.

TN0537 v9 GPSai Sheet Image 3

Caris GPSai can be added to any solid tumor order by selecting the appropriate box on the Caris requisition at no additional cost or added specimen requirements. Results for Caris GPSai will appear in the final Caris report. By comparing the genomic and transcriptomic characteristics of a patient’s tumor to the 90 cancer type signatures, these findings can offer additional insights to make more informed treatment decisions.

Example Caris Report: Caris GPSai (Genomic Probability Score)

Caris GPSai is not available in New York. For EU countries Caris GPSai reports results for 21 cancer types.
  1. Massard C, Loriot Y, Fizazi K. Carcinomas of an unknown primary origin–diagnosis and treatment. Nat Rev Clin Oncol. 2011 Nov 1;8(12):701-10. doi: 10.1038/nrclinonc.2011.158. PMID: 22048624
  2. Peck, M., Moffat, D., Latham, B., Badrick, T., Review of diagnostic error in anatomical pathology and the role and value of second opinions in error preventions, J. Clin. Pathol. 71 (11) (2018) 995-1000.
  3. Graphic generated using OncoTree framework. See Kundra, R., et al (2021) OncoTree: A Cancer Classification System for Precision Oncology. JCO Clin Cancer Inform 5, 221-230

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