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The Genomic, Transcriptomic, and Immunological Landscape of Sodium-glucose cotrasporter 2 in Lung Cancer and Association with Clinical Outcomes

– Caris Life Sciences

Poster

Conclusions

  • SLC5A2 expression was associated with a highly altered genomic landscape in AC
  • In specific subgroups, high expression of SLC5A2 was associated with OS and TOT with immunotherapy
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  • The mechanism of mismatch repair deficiency (MMRd) informs survival outcomes derived from immune checkpoint blockade (ICB) across MMRd solid tumors

    – Caris Life Sciences

    Manuscript

    Background MMRd/Microsatellite instability (MSI) High tumors represent the first tumor-agnostic indication for ICB. Emerging data suggest that the specific MMR protein lost and the mechanism… […]

  • Characterization of Plasma Cell-Free DNA Variants as ofTumor or Clonal Hematopoiesis Origin in 16,812 Advanced Cancer Patients

    – Caris Life Sciences

    Manuscript

    Abstract Purpose: Plasma-based liquid biopsy tests can detect tumorspecific genetic alterations and offer many advantages that complement tissue-based comprehensive genomic profiling. However, age-related clonal hematopoiesis… […]
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