Background
- STEAP1 and 2 (six-transmembrane epithelial antigen of prostate) are metalloreductase proteins involved in a variety of biologic processes.
- STEAP1/2 are tumor-associated cell surface antigens highly expressed in prostate cancer (PC), although their role in cancer is poorly understood.
- STEAP1/2 have emerged as potentially successful targets for adoptive T-cell therapy trials for PC.
- Ultimately, the involvement of STEAP proteins in prostate cancer pathogenesis is apparent; however, its regulation and specific role in driving cancer progression remain largely undefined.
- We employed a multi-omics approach to investigate the molecular features associated with STEAP1 and STEAP2 expression in PC