To the Editor:
We recently documented in “MAD::NUT-fusion sarcoma: A sarcoma class with NUTM1, NUTM2A, and NUTM2G fusions and possibly distinctive subtypes” in this journal1 the first known instances of NUT-rearranged sarcomas harboring fusions that do not include the NUTM1 genednamely other members of the NUT family, NUTM2A and NUTM2G. NUT-rearranged cancers encompass a heterogeneous spectrum of malignancies that include sarcomas, porocarcinomas, and, particularly, NUT carcinomas. NUT carcinoma generally presents as a poorly differentiated neoplasm occurring at any age but typically within adolescents and young adults, with a reported median survival of only 6 to 7 months.2 Definitive diagnosis requires the demonstration of a fusion between the NUTM1 gene with an expanding list of partners, such BRD4,3 BRD3,4 NSD3,5 and the zinc finger proteins6 ZMYND8, ZNF532, and ZNF592. Here, we document the first cases of NUT carcinoma harboring a NUT family gene fusion that does not involve NUTM1.