Background
- Cyclin E1 (CCNE1) expression has been associated with replicative stress and defects in double-strand break repair in multiple tumor types1
- An association between CCNE1 expression and genomic instability in ovarian cancer (OC) has not currently been demonstrated
- Here, we describe CCNE1 DNA amplification (AMP), messenger RNA (mRNA) expression, and protein expression in 2 large cohorts of high-grade serous OC (HGSOC) (The Cancer Genome Atlas [TCGA] and Caris Life Sciences, Phoenix, AZ, USA)