Uncovering actionable genetic alterations and immune predictive biomarkers for anal squamous cell carcinomas in the era of immunotherapy PD-L1 and Beyond

Authors:

Gaurav Sharma, Yasmine Baca, Joanne Xiu, Alex Farrell, George Sledge, Anwaar Saeed, Anthony Shields, Ajay Prakash, Sanjay Goel, Benjamin Weinberg, Emil Lou

Background:

Squamous cell carcinoma of the anal canal (SCAC) is a rare cancer with limited effective treatments. Immune checkpoint inhibitors (ICIs) use is routine for recurrent/refractory disease, but predictive biomarkers remain elusive. We analyzed the largest dataset of SCAC to date, focusing on PD-L1 expression.

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