Uncovering actionable genetic alterations and immune predictive biomarkers for anal squamous cell carcinomas in the era of immunotherapy PD-L1 and Beyond


Gaurav Sharma, Yasmine Baca, Joanne Xiu, Alex Farrell, George Sledge, Anwaar Saeed, Anthony Shields, Ajay Prakash, Sanjay Goel, Benjamin Weinberg, Emil Lou


Squamous cell carcinoma of the anal canal (SCAC) is a rare cancer with limited effective treatments. Immune checkpoint inhibitors (ICIs) use is routine for recurrent/refractory disease, but predictive biomarkers remain elusive. We analyzed the largest dataset of SCAC to date, focusing on PD-L1 expression.

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