Tumor profiling on 1245 gliomas and paired tumor study on 19 high grade gliomas

Authors:

Joanne Xiu, David Spetzler, Ryan Bender, Anatole Ghazalpour, Zoran Gatalica, Sandeep K. Reddy, David Piccioni, Jethro Hu, Michael J. Glantz, Santosh Kesari

Background

Gliomas are molecularly heterogeneous with genetic alterations driving the growth of recurrences different from the initial tumor. Previous reports showed molecular changes during progression of lower grade gliomas to GBM, driving tumor growth and treatment resistance; however changes during progression of high-grade gliomas have not been systematically reported.

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