Tumor profiling of biliary tract carcinomas reveals distinct molecular alterations and potential therapeutic targets


Randall F. Holcombe, Joanne Xiu, Michael J. Pishvaian, Sherri Z. Millis, Zoran Gatalica, Sandeep K. Reddy, Jason K. Sicklick, Paul T. Fanta, Santosh Kesari, Michael A. Morse


Extrahepatic cholangiocarcinoma (EHCC), intrahepatic cholangiocarcinoma (IHCC), and gallbladder carcinoma (GBCA) are rare tumors with poor prognosis that tend to be chemo-resistant. The underlying molecular alterations and their correlation with altered responses to therapies are not well understood. We hypothesized that delineation of different molecular alterations in the cancer types might potentially yield different therapeutic options.

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