Transcriptome Analysis and Theranostic Profiling of Ewing Sarcoma (ES) and Desmoplastic Small Round Cell Tumors (DSRCT)


Wenhsiang Wen, Anatole Ghazalpour, Wangjuh (Sting) Chen, Brian Rhees, Matthew J. McGinniss, and Zoran Gatalica


Ewing Sarcoma (ES)/PNET and Desmoplastic Small Round Cell Tumor (DSRCT) are sarcomas with distinct chromosomal translocations involving the EWS gene (predominately EWS-FLI1 and EWS-WT1; respectively). Their diagnosis and treatment have been difficult due to the rarity, diverse clinical presentation, overlapping histologic features and genetic complexity. Identification of therapeutically targetable genes or pathways in distinct tumor group and individual patient might provide more effective therapeutic strategies.

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