The tumor microenvironment and immune infiltration landscape of KRAS mutant pancreatic ductal adenocarcinomas (PDAC) compared to colorectal adenocarcinomas (CRC)


Emil Lou, Joanne Xiu, Yasmine Baca, Phillip Walker, Gulam Abbas Manji, Sepideh Gholami, Anwaar Saeed, Philip Agop Philip, Ajay Prakash, Igor A. Astsaturov, Greg Botta, Laith I. Abushahin, Davendra Sohal, Heinz-Josef Lenz, Anthony Frank Shields, Chadi Nabhan,Wafik S. El-Deiry, Andreas Seeber, Wolfgang Michael Korn

Key Finding:

The tumor microenvironment of pancreatic ductal carcinomas harboring KRAS mutations shows similar patterns to that of KRAS mutant colorectal cancers and presents with immune-cold features. 

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