The prognostic significance of TP53 mutations in patients with right-sided and left-sided colorectal cancer


Moh’d M. Khushman, Nishant Gandhi, Joanne Xiu, Bassel El-Rayes, Andreas Seeber, Grant Richard Williams, Darryl Alan Outlaw, Emil Lou, Anthony Frank Shields, Philip Agop Philip, Wafik S. El-Deiry, John Marshall, Priya Jayachandran, Heinz-Josef Lenz, Matthew James Oberley, Wolfgang Michael Korn, Upender Manne

Key Finding:

While the prevalence of gain-of-function and non-gain-of-function TP53 mutations is higher in left-sided colorectal cancer versus right-sided, these mutations are associated with a worse median overall survival only for patients with right-sided colorectal cancer. 

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