The presence of estrogen and progesterone receptors in uterine carcinosarcoma is associated with improved survival and increased immunogenicity


Nathaniel L. Jones, Sharon Wu, Joanne Xiu, Rodney Paul Rocconi, Britt Kristina Erickson, Premal H. Thaker, Jubilee Brown, Thomas J. Herzog, Robert W. Holloway, Wolfgang Michael Korn, Matthew A. Powell, Annelise M Wilhite

Background: Recent data has shed light on molecular profiles of uterine carcinosarcoma (UCS), but few have correlated molecular profiles with prognosis. In a preliminary data analysis, we found that hormone receptors (HR)—estrogen receptor (ER) and progesterone receptor (PR)—expression was associated with improved OS. Here, we investigate the molecular profile differences between ER+/- and PR +/- tumors.

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