The molecular landscape of PIWIL1 expression in colorectal adenocarcinoma CRC


Tony Varughese, Yasmine Baca, Lishann Ingram, Gretchen Hubbard, Joanne Xiu, Emil Lou, Hiroyuki Arai, Anthony Shields, Moh’d Khushman, Francesca Battaglin, Jimmy Hwang, Richard Goldberg, Andreas Seeber, Heinz-Josef Lenz, Sanjay Goel, John Marshall, Matthew Oberley, Benjamin Weinberg


PIWIL1 is a cancer testis antigen overexpressed in solid tumors, particularly CRC, and is associated with advanced stage and poor prognosis. It is potentially a new therapeutic target, as PIWIL1 is not expressed in adult somatic tissue. A novel T cell receptor/PIWIL1 bispecific antibody is in development and restricted to individuals with human leukocyte antigen (HLA) A-02. We sought to characterize the molecular landscape of PIWIL1 in CRC.

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