The genomic transcriptomic and immunologic landscape of TEM8 ANTXR1 in Small Cell Lung Cancer SCLC

Authors:

Samuel Kareff, Harris Krause, Andrew Elliott, Gilberto Lopes, Emil Lou, Heloisa Soares, Matthew Oberley, Aman Chauhan

Background:

  • The TEM8 receptor (ANTXR1) is overexpressed in malignant tissues, with novel oncolytic viruses such as SVV-001 uniquely binding on tumor-associated angiogenic endothelial cells, pericytes, fibroblasts, and immune inflammatory cells
  • Recent pre-clinical data suggest that TEM8-targeting therapies may convert immunologically “cold” tumor microenvironments (TMEs) into “hot” milieu more amenable to treatment with immune checkpoint inhibitors (ICIs)
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