The genomic, transcriptomic, an immunological profile of patients with recurrent refractory NSCLC

Authors:

Dan Morgenstern Kaplan, Samuel Kareff, Nishant Gandhi, Andrew Elliott, Marco Magistri, Daniel Sumarriva, Ari Vanderwalde, Ana Salazar, Patrick Ma, Balazs Halmos, Coral Olazagasti, Gilberto Lopes, Hina Khan, Estelamari Rodriguez

Background:

  • Lung cancer is the leading cause of cancer-related deaths worldwide, and >50% of patients present as stage III or IV.
  • Recently, patients with relapsing/remitting stage III NSCLC (R/R) were described to have worse overall survival compared to de novo stage IV (DN) patients when treated with chemoradiation and immunotherapy.
  • In this study, we aimed to compare the molecular and immune landscapes of these two patient populations to identify potential differences in biomarkers of resistance and possible targets for therapy.
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