PI3K/PTEN/Akt/mTOR pathway aberrations and co-incidence of hormone receptors and HER2 in 19,784 diverse solid tumors

Authors:

Sherri Z. Millis, Sadakatsu Ikeda, David Arguello, Rebecca Feldman, Joanne Xiu, Todd Maney, Sandeep Reddy, and Razelle Kurzrock

Background

Molecular aberrations in the phosphatidylinositol 3-kinase (PI3K) pathway have been documented across cancers, especially PIK3CA mutations and mutation or loss of PTEN. These alterations may be relevant to therapies targeting the PI3K/PTEN/Akt/mTOR signaling pathway.

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