PI3K/PTEN/Akt/mTOR pathway aberrations and co-incidence of hormone receptors and HER2 in 19,784 diverse solid tumors


Sherri Z. Millis, Sadakatsu Ikeda, David Arguello, Rebecca Feldman, Joanne Xiu, Todd Maney, Sandeep Reddy, and Razelle Kurzrock


Molecular aberrations in the phosphatidylinositol 3-kinase (PI3K) pathway have been documented across cancers, especially PIK3CA mutations and mutation or loss of PTEN. These alterations may be relevant to therapies targeting the PI3K/PTEN/Akt/mTOR signaling pathway.

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