PD-L1 and alternative immune checkpoints AICs in non-small cell lung cancer NSCLC Insights into the tumor immune microenvironment TIME and immunotherapy IO outcomes

Authors:

Angelica D’Aiello, Shayan Nazari, Hyein Jeon, Andrew Elliott, Ari Vanderwalde, Hossein Borghaei, Stephen Liu, Xingxing Zang, Balazs Halmos, Haiying Cheng

Background:

  • We previously showed that HHLA2 is expressed in ~2/3NSCLC and associated with EGFR mutation status (1), and that the majority of PD-L1 neg NSLCC express B7x and HHLA2 (2)
  • We sought to explore patterns of PD-L1 and AICs within the TIME and impact on IO outcomes
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