Pan-Cancer Analysis of Natural Killer (NK) Cell Infiltration in Human Malignancies: Molecular Features and Clinical Implications


Nick Zorko, Justin Hwang, John Lozada, Hilary Seifert, Andrew Elliott, Milan Radovich, George Sledge, Martin Felices, Elisabeth Heath, Dave Hoon, Wafik El-Deiry, Jeffrey Miller, Emmanuel Antonarakis


  • High NK cell infiltration is associated with improved OS in numerous cancers.
  • These findings suggest broad deployment of NK engagers and CAR-NK.
  • The positive correlation between NK cells and LAG3/TIGIT suggest that combination approaches may be warranted.
  • These findings support the use of NK cells in situations where other immune therapies have proven to be ineffective.
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