Molecular profiling of HPV-positive and -negative HNSCC


Rebecca Feldman Ph.D., Anatole Ghazalpour, Ph.D., Joseph Knezetic, Ph.D., Zoran Gatalica, M.D., Panayiotis S. Savvides, M.D., Theodoros N. Teknos, M.D.


Head and neck squamous cell carcinoma (HNSCC) is comprised of two subtypes: human papilloma virus (HPV)-and carcinogenic-associated (HPV-negative), both linked to inactivation of the TP53 pathway. We examined alterations in HPV positive (pos) and negative (neg) HNSCC to identify treatment options and elucidate differences in pathogenesis.

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