Molecular Profiling of Aggressive Variant Urothelial Carcinoma
C Ramamurthy, D Arguello, F Anari, E Plimack, M Zibelman, P Ghatalia, EF Burgess, T Hogan , NA Dawson, R Hauke, JB Aragon-Ching, D Vaena, B Somer, E Heath, D Geynisman
The WHO recognizes multiple variant histologies of urothelial carcinoma (vUC), many of which have been associated with poor outcomes compared with UC (UC).
Prior studies have identified molecular differences between variant vUC and UC through targeted techniques, for example, HER2 gene amplification in micropapillary histology or CDH1 loss is plasmacytoid histology.
We aimed to explore molecular differences between aggressive vUC and UC using multiplatform profiling.