Molecular correlates of DSCR1 expression in pancreatic cancer (PDAC)

Authors:

Francesca Battaglin, Yasmine Baca, Joanne Xiu, Phillip Walker, Shivani Soni, Jae Ho Lo, Jingyuan Wang, Sandra Algaze, Priya Jayachandran, Pooja Mittal, Lesly Torres-Gonzalez, Wu Zhang, Richard Goldberg, Benjamin Weinberg, Emil Lou, Anthony Shields, John Marshall, Sanjay Goel, Fariborz Nasertorabi, Heinz-Josef Lenz

Conclusions

  • This is the first and most extensive profiling study to investigate DSCR1 expression in PDAC.
  • Our data show a strong association between tumor DSCR1 gene expression, several pathway alterations, immune-related gene expression, TME cell infiltration and patient survival.
  • These findings suggest DSCR1 as a candidate prognostic biomarker and as a potential treatment target in PDAC.
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