Molecular correlates of DSCR1 expression in pancreatic cancer (PDAC)


Francesca Battaglin, Yasmine Baca, Joanne Xiu, Phillip Walker, Shivani Soni, Jae Ho Lo, Jingyuan Wang, Sandra Algaze, Priya Jayachandran, Pooja Mittal, Lesly Torres-Gonzalez, Wu Zhang, Richard Goldberg, Benjamin Weinberg, Emil Lou, Anthony Shields, John Marshall, Sanjay Goel, Fariborz Nasertorabi, Heinz-Josef Lenz


  • This is the first and most extensive profiling study to investigate DSCR1 expression in PDAC.
  • Our data show a strong association between tumor DSCR1 gene expression, several pathway alterations, immune-related gene expression, TME cell infiltration and patient survival.
  • These findings suggest DSCR1 as a candidate prognostic biomarker and as a potential treatment target in PDAC.
Download Publication