Molecular correlates of Delta-like-ligand 3 (DLL3) expression in neuroendocrine neoplasms (NENs)


Justin Hwang, Julie McGrath, John R. Lozada, Pavel Brodskiy, Joanne Xiu, Shuanzeng Wei, Elisabeth I. Heath, Benedito A. Carneiro, Emil Lou, Helosia P. Soares, Rana R. McKay, Emmanuel S. Antonarakis, Charles Ryan David Spetzler, Himisha Beltran

Key Finding:

DLL3-H expression was associated with “undruggable” genomic features, and may serve as a target for for neuroendocrine neoplasm patients with functional loss of tumor suppressors TP53 and RB1, as well as increased activity of KRAS, WNT and MYC signaling. 

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