Molecular Characterization of Bladder Cancer in Smokers versus Nonsmokers


Monika Joshi, MD, MRCP, Sherri Z. Millis, MS, PhD, Donald Lamm, MD, Sandeep Reddy, MD, Sheldon L. Holder, MD, PhD, Nicholas J. Vogelzang, MD, Joseph J. Drabick, MD


  • Bladder cancer (BC) is one of the most common malignancies of the urinary tract and is the 4th most common cancer among men.
  • It is estimated that by the end of 2015, the US will have approximately 74,000 new BC cases, accounting for 16,000 cancer- related deaths.
  • Smoking is considered an important risk factor for BC. Recent data demonstrate an increase in BC incidence in nonsmokers as well.
  • Molecular characterization of BC in nonsmokers has not been wellstudied.

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