Molecular characterization of 361 cases of uterine carcinosarcomas reveal alterations in the DNA repair and PI3K pathways as potential therapeutic targets


Nathaniel L Jones, Joanne Xiu, Sandeep K. Reddy, Ana I. Tergas, William M. Burke, Jason D. Wright, June Y. Hou

Background: Uterine carcinosarcomas (malignant mixed Müllerian tumors or MMMT) are rare endometrial cancers (EC) composed of epithelial and mesenchymal components. MMMTs exhibit aggressive behavior with poor prognosis. We aim to evaluate patterns of molecular, genomic and protein changes in a large cohort of uterine carcinosarcomas and identify potential treatment options.

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