Medulloblastoma candidate pathways for novel treatment strategies


Tiffany R. Hodges1, Nader Sanai4, Joanne Xiu5, Lyndon Kim6, Shouhao Zhou2, Santosh Kesari7, Marta Penas-Prado3, Amy Heimberger1

BACKGROUND: Medulloblastoma, an aggressive but potentially curable CNS disease, remains a treatment challenge due to the biological heterogeneity of the disease. Analysis of actionable targets can provide opportunities in the development of curative therapies. To identify potential candidate genes, we investigated alterations in a cohort of medulloblastoma patients.

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