KRAS Mutations and Prognostic Implications in Appendiceal Cancers

Authors:

Snigdha Nutalapati, Negar Sadeghipour, Joanne Xiu, Sharon Wu, Heinz Josef Lenz, Ryan Schmocker, Matthew Oberley, Anna Reagan, Hannah McDonald, Reema Patel, Sanjay Goel, Prakash Pandalai, Joseph Kim

Introduction:

  • Despite shared embryonic origin, appendiceal cancers (AC) have distinct clinical and molecular features compared to colorectal cancers (CRC).
  • Detection of mutant KRAS has been associated with worse survival in CRC, whereas in AC the prognostic significance of mutant KRAS (55-65% prevalence) has yet to be characterized.
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