KRAS Mutations and Prognostic Implications in Appendiceal Cancers


Snigdha Nutalapati, Negar Sadeghipour, Joanne Xiu, Sharon Wu, Heinz Josef Lenz, Ryan Schmocker, Matthew Oberley, Anna Reagan, Hannah McDonald, Reema Patel, Sanjay Goel, Prakash Pandalai, Joseph Kim


  • Despite shared embryonic origin, appendiceal cancers (AC) have distinct clinical and molecular features compared to colorectal cancers (CRC).
  • Detection of mutant KRAS has been associated with worse survival in CRC, whereas in AC the prognostic significance of mutant KRAS (55-65% prevalence) has yet to be characterized.
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