Interplay between B cell and GABA metabolism (GABAm) reveals potential immune evasion in breast carcinoma (BC)

Authors:

Frances Elaine Chow, Irene Kang, Jun Yin, Alex Farrell, Vahan Martirosian, Priya Jayachandran, Evanthia T. Roussos Torres, Janice M. Lu, Heinz-Josef Lenz, Cynthia X. Ma, Heather L. McArthur, Reva K Basho, David Spetzler, Josh Neman

Background

GABAergic signaling has been reported to play a pivotal role in breast cancer (BC) tumorigenesis and metastasis, however, its role in immune modulation remains unclear. Recent in vitro and in vivo studies [1] report the role of B cell-derived GABA metabolites in promoting anti-inflammatory macrophages (MM), thus limiting anti-tumor immunity. In this study, we aim to characterize the interplay between B cells and the GABAm pathway, as well as their associated immune infiltrates and cytokines.

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