Interplay between B cell and GABA metabolism (GABAm) reveals potential immune evasion in breast carcinoma (BC)


Frances Elaine Chow, Irene Kang, Jun Yin, Alex Farrell, Vahan Martirosian, Priya Jayachandran, Evanthia T. Roussos Torres, Janice M. Lu, Heinz-Josef Lenz, Cynthia X. Ma, Heather L. McArthur, Reva K Basho, David Spetzler, Josh Neman


GABAergic signaling has been reported to play a pivotal role in breast cancer (BC) tumorigenesis and metastasis, however, its role in immune modulation remains unclear. Recent in vitro and in vivo studies [1] report the role of B cell-derived GABA metabolites in promoting anti-inflammatory macrophages (MM), thus limiting anti-tumor immunity. In this study, we aim to characterize the interplay between B cells and the GABAm pathway, as well as their associated immune infiltrates and cytokines.

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