Identification of actionable targets for breast cancer intervention using a diversity outbred mouse model

Authors:

Jennifer B Jacob 1, Kuang-Chung Wei 1, Gerold Bepler 1, Joyce D Reyes 1, Andi Cani 2, Lisa Polin 1, Kathryn White 1, Seongho Kim 1, Nerissa Viola 1, Julie McGrath 3, Anthony Guastella 3, CongCong Yin 4, Qing-Shen Mi 4, Benjamin L Kidder 1, Kay-Uwe Wagner 1, Stuart Ratner 1, Victoria Phillips 1, Joanne Xiu 3, Prahlad Parajuli 1, Wei-Zen Wei 1

Highlights

  • HER2/Neu-expressing diversity outbred F1 mice enable genetic linkage analysis
  • 26 Genes in 3 quantitative trait loci (QTL) predicted breast cancer survival
  • The myeloid checkpoint gene, LILRB4, emerged as an actionable intervention target
  • TIEG1 suppresses tumor growth and is critical to regulatory T cell development
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