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Identification and prognostic impact of PBRM1 mutations in biliary tract cancers: Results of a comprehensive molecular profiling study

Authors:

Kai Zimmer, Florian Kocher, Gerold Untergasser, Alberto Puccini, Joanne Xiu, Dominik Wolf, Gilbert Spizzo, Richard M. Goldberg, Axel Grothey, Anthony Frank Shields, John Marshall, Michael J. Hall, Wolfgang Michael Korn, Chadi Nabhan, Francesca Battaglin, Heinz-Josef Lenz, Wafik S. El-Deiry, Arno Amann, David Hsiehchen, Andreas Seeber

Background / Aim of the project
•Novel treatment strategies are needed to improve survival for biliary tract cancers (BTC) (1).
•Polybromo-1 (PBRM1) is a tumor suppressor gene that is involved in chromatin remodeling (2).
•Preclinical studies suggest induction of synthetic lethality by PARP inhibitors in PBRM1-mutated renal cell carcinoma (3).

Aim of the project:
•To describe the molecular and immunological landscape of PBRM1-mutated biliary tract cancers.

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