Identification and characterization of immunogenic neoantigens in colorectal cancer (CRC)

Authors:

Francesca Battaglin, Andrew Elliott, Joanne Xiu, Sandra Algaze, Jingyuan Wang, Priya Jayachandran, Shivani Soni, Karam Ashouri, Alexandra Wong, Pooja Mittal, Jae Ho Lo, Lesly Torres-Gonzalez, Wu Zhang, Benjamin Adam Weinberg, Anthony F. Shields, Richard M. Goldberg, John Marshall, Emil Lou, Heinz-Josef Lenz

Key Finding:

  • In one of the largest studies to investigate the landscape of immunogenic neoantigens in CRC to date, candidate recurrent peptides with high HLA binding affinity and associated with a positive T cell inflammation signature (TIS) were identified, supporting the role of neoantigens as potential cancer immunotherapy targets.