HPV-induced cervical, oropharyngeal and anal carcinoma share theranostic biomarkers


Nooshin Hashemi Sadraei, MD, Rebecca Feldman, PhD, Zoran Gatalica, MD DSc, Sandeep Reddy, MD, Patrick Boland, MD, Krishnansu S. Tewari

Background: Several distinct cancers are caused by human papillomavirus (HPV)-including squamous cell carcinomas of the cervix (CSCC), anal canal (ASCC), and oropharynx (OSCC). Importantly, platinum based chemoradiation protocols are similarly effective in these entities. We assessed CSCC, ASCC, and OSCC for additional evidence of shared characteristics which could be used to identify potential molecular targets across the spectrum of HPV induced cancers.

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