Gliosarcoma vs. glioblastoma: a retrospective case series using molecular profiling


Christopher Dardis 1, David Donner 2, Nader Sanai 3, Joanne Xiu 4, Sandeep Mittal 5, Sharon K Michelhaugh 5, Manjari Pandey 6, Santosh Kesari 7, Amy B Heimberger 8, Zoran Gatalica 9, Michael W Korn 4, Ashley L Sumrall 10, Surasak Phuphanich 11


Gliosarcoma (GS) refers to the presence of mesenchymal differentiation (as seen using light microscopy) in the setting of glioblastoma (GB, an astrocytoma, WHO Grade 4). Although the same approach to treatment is typically adopted for GS and GB, there remains some debate as to whether GS should be considered a discrete pathological entity. Differences between these tumors have not been clearly established at the molecular level.

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