Genomic landscape and prognostic impact of HER2 low-expressing tumors

Authors:

Aditya Shreenivas, Andrew Elliott, Tom Corbiere, Joanne Xiu, Jeff Hirst, Hui-Zi Chen, Ben George, Mandana Kamgar, Sakti Chakrabarti, Aakash Desai, Yanis Boumber, Charalampos S. Floudas, Dara Bracken-Clarke, Elisabetta Xue, Jacob Thomas, Razelle Kurzrock

Background

  • There is evolving evidence that HER2 low-expressing (1+/2+ IHC) tumors may respond to novel anti-HER2-based therapies.
  • We evaluated the frequency and prognostic impact of HER2 expression and its association with ERBB2 genomic alterations in a large database of molecularly profiled tumors from real-world patients (pts).
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