Genomic Landscape and Immune Phenotype of Malignant Pleural Mesothelioma


Meera Patel, Andrew Elliott, Stephen V. Liu, Chul Kim, Luis E. Raez, Rebecca Feldman, Sachin G. Pai, Antoinette J. Wozniak, Misako Nagasaka, Gilberto Lopes, Alexander I. Spira, Edward S. Kim, W. Michael Korn, Hirva Mamdani


The majority of MPM tumors harbor alteration in one of the key cellular pathways. • HR pathway mutations are the most common. • The majority of tumors were PD-L1 negative and carry low TMB indicating low immunogenicity. No age and gender specific differences exist except for BAP1 and SETD2 mutations.

Download Publication