Gene expression of NANOG and NANOGP8 in colorectal cancer
Jingyuan Wang1, Natsuko Kawanishi1, Priya Jayachandran1, Shivani Soni1, Wu Zhang1, Daniel Magee2, W. Michael Korn2, Heinz-Josef Lenz1Hiroyuki Arai1, Yasmine Baca2, Joanne Xiu2, Francesca Battaglin1, Jimmy J. Hwang3, John Marshall4, Richard M. Goldberg5, Benjamine Weinberg4, Davendra Sohal6, Emil Lou7, Michael J. Hall8
The cancer stem cell (CSC) possesses self-renewal and multilineage differentiation potential, and believed to be responsible for resistance to chemotherapy and/or radiotherapy .
NANOG is a pluripotency transcription factor that serves as a signaling hub in maintaining CSCs [2-3].
Full-length NANOG protein is encoded by two paralogs of gene, namely NANOG1 (generally referred as NANOG) and NANOGP8 .
NANOG mediates immune evasion through NANOG/TCL1A/AKT and NANOG/LC3B/EGFR axes, contributing to immune resistant phenotype [5-7].
This study aimed to clarify molecular characters relating to gene expression levels of NANOG and NANOGP8 in patients with colorectal cancer (CRC).