Fusion analysis of solid tumors to reveal novel rearrangements in breast carcinomas


Igor Astsaturov, Philip Ellis, Jeff Swensen, Zoran Gatalica, David Arguello, Sandeep Reddy, Wafik El-Deiry

Introduction to gene fusion
• Fusions of genes are common events in epithelial cancers
• Recurrent fusions arise as the result of genomic rearrangements or abnormal processing of mRNA
• Proteins translated from gene fusions are potential drug targets

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