FOXL2 mutation is prevalent in metastatic adult granulosa cell tumors and is associated with improved survival


Emily C MacArthur, Alison A. Garrett, Sharon Wu, Joanne Xiu, Jubilee Brown, Robert W. Holloway, Thomas J. Herzog, Premal H Thaker, Michael Korn, Madeleine Courtney-Brooks, Paniti Sukumvanich, Ronald Buckanovich, Robert P. Edwards, Haider Mahdi, Sarah E. Taylor, Jessica Berger, Alexander B. Olawaiye, Michelle Boisen, Lan G. Coffman, Nathaniel L Jones, Jamie Lesnock


To describe the molecular profile of adult granulosa cell tumors (AGCT) of the ovary in order to improve prognostication and elucidate molecular therapeutic targets

  • AGCT represent less than 5% of all ovarian tumors
  • Nearly 1/3 of patients with AGCT develop recurrent disease, and targeted therapies are limited
  • Existing data suggest that FOXL2 mutations are common in AGCT and may be pivotal in the development of AGCT
  • Further molecular profiling of AGCT may improve prognostication and identify novel therapeutic targets

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