Authors:
Emily C MacArthur, Alison A. Garrett, Sharon Wu, Joanne Xiu, Jubilee Brown, Robert W. Holloway, Thomas J. Herzog, Premal H Thaker, Michael Korn, Madeleine Courtney-Brooks, Paniti Sukumvanich, Ronald Buckanovich, Robert P. Edwards, Haider Mahdi, Sarah E. Taylor, Jessica Berger, Alexander B. Olawaiye, Michelle Boisen, Lan G. Coffman, Nathaniel L Jones, Jamie Lesnock
Objective:
To describe the molecular profile of adult granulosa cell tumors (AGCT) of the ovary in order to improve prognostication and elucidate molecular therapeutic targets
- AGCT represent less than 5% of all ovarian tumors
- Nearly 1/3 of patients with AGCT develop recurrent disease, and targeted therapies are limited
- Existing data suggest that FOXL2 mutations are common in AGCT and may be pivotal in the development of AGCT
- Further molecular profiling of AGCT may improve prognostication and identify novel therapeutic targets
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