Michelle Wedemeyer, Joanne Xiu, Phillip Walker, Jasmeet Kaur, Christian Davidson, Manmeet Ahluwalia, Ashley Sumrall, Gabriel Zada
The craniofacial patterning transcription factor FOXC1 was found to be widely expressed in a large cohort of meningiomas.
FOXC1 expression is inversely correlated with WHO tumor grade.
FOXC1low meningiomas are significantly more likely to harbor NF2 mutations than FOXC1hi meningiomas.
FOXC1 expression levels are correlated with high expression of other meningeal identify genes suggesting low levels of FOXC1 may represent dedifferentiation to a more immature state.
Multi-omic analysis reveals a significant relationship between FOXC1 transcript levels and key markers of the immune environment including PDL1 transcript expression.
Functional studies are warranted to determine whether FOXC1 is necessary for meningioma growth, whether FOXC1 plays a direct immunomodulatory role in meningiomas, and whether the lower FOXC1 expression levels in high grade tumors represent a more embryonic phenotype.