Examination of Topoisomerase I (TOPO1) Expression in Metastatic GI Cancers

Authors:

Michael Castro, M.D., Rebecca Feldman, Ph.D., Sandeep Reddy, M.D.

Background

Irinotecan failed in Stage III colon cancer, but succeeds in Stage IV, to prolong survival. We propose that TOPO1 over-expression is a phenomenon of metastatic disease, and perhaps part of the epithelial-mesenchymal-transition (EMT) associated with metastatic phenotypes.

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