Examination of Topoisomerase I (TOPO1) Expression in Metastatic GI Cancers


Michael Castro, M.D., Rebecca Feldman, Ph.D., Sandeep Reddy, M.D.


Irinotecan failed in Stage III colon cancer, but succeeds in Stage IV, to prolong survival. We propose that TOPO1 over-expression is a phenomenon of metastatic disease, and perhaps part of the epithelial-mesenchymal-transition (EMT) associated with metastatic phenotypes.

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