Authors:
Sushma Jonna 1, Ari Vanderwalde 2, Jorge Nieva 3, Kelsey Anne Poorman 4, Michelle Saul 4, Xinyu von Buttlar 5, John Y Hu 6, Stephen V Liu 5
Background: Higher tumor mutation burden (TMB) in advanced non-small cell lung cancer (NSCLC) is associated with superior outcomes with checkpoint inhibitor therapy. Tissue samples subject to TMB analysis may be acquired after DNA-damaging therapies such as chemotherapy or radiation. The impact of these therapies on TMB results is unclear. This retrospective analysis explored differences in TMB among treatment-naïve samples and treatment-experienced samples.
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