Drug Efflux Pump Expression in 50,000 Molecularly-Profiled Cancer Patients


Rebecca Feldman, PhD, Sandeep Reddy, MD, Brian Abbott, MD, Michael Castro, MD


Background: The multidrug resistance (MDR) phenotype reduces the efficacy of various chemotherapies. MDR is linked to the overexpression of ATP-binding cassette (ABC) transporters in cancer cells, including P-glycoprotein (PGP/ABCB1), multidrug resistance protein (MRP1/ABCC1) and breast cancer resistance protein (BCRP/ABCG2). We assessed protein expression patterns of the drug efflux pumps across all tumor types for insight on how to exploit MDR status to circumvent treatment dilemmas.

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