Dissecting the significance of ACP1 gene alterations in prostate cancer (PCa)


Nour Abdallah, Andrew Elliott, Chadi Nabhan, Stephanie Stanford, Neeraj Agarwal, Aditya Bagrodia, Rohan Garje, Nunzio Bottini, Rana McKay



  • The acid phosphatase 1 (ACP1) gene encodes low molecular weight protein tyrosine phosphatase (LMPTP), which is overexpressed in PCa.
  • Previous studies demonstrate that LMPTP plays a critical role in PCa growth and metastasis and is evolving as a potential therapeutic target.
  • Thus, we analyzedACP1expression in primary and metastatic PCa samples and the association ofACP1with molecular profiles and clinical outcomes.
Download Publication