Detection of NRG1 Fusion Events in Ovarian, Fallopian Tube, and Primary Peritoneal Carcinomas

Authors:

Mark G. Evans 1, Anthony Crymes 2, Jack Reid 3, Matthew J. Oberley 1, Jill H. Tseng 3

Introduction

  • NRG1 has been explored as the target of emerging HER2/HER3-directed anti-cancer agents, and the recent discovery of NRG1 fusion events may have important therapeutic implications.
  • While these fusions are relatively uncommon, they have been most thoroughly described in lung and pancreaticobiliary neoplasms.
  • A recentstudybyGuptaetal. reported over 150NRG1fusion partners in a wide variety of tumor types.
  • This study seeks to further characterize NRG1 fusions in ovarian, fallopian tube, and primary peritoneal carcinomas.
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