Detection of Lung Cancer From Plasma Using the Biosignature of Circulating Microvesicles


Andrea Tasinato, Gherici Hassaine, Elodie Ristorcelli, Wang-Juh Chen and Christine Kuslich


Circulating microvesicles (cMV) are cell-derived structures that are abundantly present in the blood. Tumor cells produce large quantities of cMV, and their amount has been shown to correlate with tumor invasiveness and resistance to therapy. This study attempts to understand the origin, composition, and potential clinical utility of cMV, analyzing their protein
composition in patients with non–small cell lung cancer (NSCLC) and identifying a cMV-based biosignature that can be used to predict the presence of tumors from a blood sample.

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