CXCR4 overexpression: an indicator of poor survival and predictor of response to immunotherapy in patients with metastatic colorectal cancer


Sepideh Gholami, Yasmine Baca, Pavel Brodskiy, Joanne Xiu, Gulam Abbas Manji, Andreas Seeber, Anwaar Saeed, Benjamin Adam Weinberg, Moh’d M. Khushman, Rachna T. Shroff, Jim Abraham, Anthony Frank Shields, Heinz-Josef Lenz, John Marshall, Wolfgang Michael Korn, Emil Lou

Key Finding:

Colorectal cancer patients with high tumoral CXCR4 expression had improved survival when treated with pembrolizumab. 

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