Correlation of tumor mutational burden (TMB) with CDKN2A and TP53 mutations


Barbara Burtness, Alexander Y Deneka, Yasmine Baca, Ilya G. Serebriiskii, Mitchell I Parker, Emmanuelle Nicolas, Jong-Woo Lee, Trisha Wise-Draper, Ammar Sukari, Erica A Golemis


Mutation of TP53 and/or CDKN2A is associated with increased mean TMB relative to WT. • Mean TMB was highest for tumors bearing damaging mutations in both genes. • GOF TP53 mutation was not associated with increased TMB; however, this analysis had less power due to smaller number of cases with GOF TP53.

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