Comprehensive profiling of clock genes expression in hepatocellular carcinoma (HCC)


Francesca Battaglin, Yasmine Baca, Joanne Xiu, Shivani Soni, Sandra Algaze, Priya Jayachandran, Evanthia Roussos Torres, Shannon Mumenthaler, Jae Ho Lo, Pooja Mittal, Wu Zhang, Richard Goldberg, Benjamin Weinberg, Emil Lou, Anthony Shields, John Marshall, Sanjay Goel, Anthony El-Khoueiry, Steve Kay, Heinz-Josef Lenz


  • This is the most extensive profiling study to investigate the expression of clock genes in HCC.
  • Our data show that clock genes expression impacts patient survival and is associated with alterations in immune-related gene expression and TIS score which suggest a role in the modulation of anti-tumor immunity.
  • These results support the clock pathway role as a oncogenic driver and its potential as a therapeutic target in HCC.
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