Comprehensive Molecular Mapping of Pancreatic Ductal Adenocarcinoma Relates XPO1 mRNA Expression Levels to Potential Clinical Targets


Andreas Seeber, Rebecca Gruber, Florian Kocher, Kai Zimmer, Alberto Puccini, Harris Krause, Daniel Neureiter, Eckhard Klieser, Stefan Salcher, Agnieszka Martowicz, Emil Lou, Wafik El-Deiry, Elisa Fontana, Pat Gulhati, Moh’d Khushman, Dominic Fong, Heinz-Josef Lenz, Domink Wolf, Matthew Oberley, Viktorija Sokolova


  • This is the first study comprehensively mapping XPO1 mRNA expression and immune-correlates in PDAC.
  • We found that high XPO1 is linked to increased immune cell infiltration and more T cell-inflamed tumors.
  • Our data provides a potential rationale to combine immune checkpoint therapy (+/- XPO1 inhibitors) in XPO1H PDACs.
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